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A study published this week in the journal Carcinogenesis shows that in both cell lines and mouse models, grape seed extract (GSE) kills head and neck squamous cell carcinoma cells, while leaving healthy cells unharmed.
"It's a rather dramatic effect," says Rajesh Agarwal, PhD, investigator at the University of Colorado Cancer Center and professor at the Skaggs School of Pharmaceutical Sciences.
Grape seed extract kills head and neck cancer cells, leaves healthy cells unharmed
Seeded on Fri Jan 27, 2012 6:42 PM EST
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Grape seed extract creates these conditions that are unfavorable to growth. Specifically, the paper shows that grape seed extract both damages cancer cells' DNA (via increased reactive oxygen species) and stops the pathways that allow repair (as seen by decreased levels of the DNA repair molecules Brca1 and Rad51 and DNA repair foci).
"Yet we saw absolutely no toxicity to the mice, themselves," Agarwal says.
Again, the grape seed extract killed the cancer cells but not the healthy cells.
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